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» تقدير بعض الأدوية المسكنة للآلام في المادة النقيّة والمستحضرات الصيدلانية باستخدام اقطاب انتقائية جديدة Determination of Some Analgesic Drugs in Pure and Dosage Forms Using a New Ion Selective Electrodes
تقدير بعض الأدوية المسكنة للآلام في المادة النقيّة والمستحضرات الصيدلانية باستخدام اقطاب انتقائية جديدة Determination of Some Analgesic Drugs in Pure and Dosage Forms Using a New Ion Selective Electrodes
رسالة متاحة للتحميل :
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تقدير بعض الأدوية المسكنة للآلام في المادة النقيّة والمستحضرات الصيدلانية باستخدام اقطاب انتقائية جديدة
Determination of Some Analgesic Drugs in Pure and Dosage Forms Using a New Ion Selective Electrodes
لـ : فاضل ابراهيم خسين الجابري
ماجستير الكيمياء التحليلية
جامعة بغداد - كلية العلوم 2015
:
SUMMARY
This thesis involves three main
chapters .
Chapter one includes an introduction
of electro analytical techniques. Ion
selective electrodes (ISEs) and its work. Molecularly imprinted
polymers technique and approaches for preparing molecularly imprinted
polymers. The research work covers in detail a comprehensive of
a full survey of the chemical literatures related with project title. The ibuprofen
and mefenamic acid.
Chapter two comprises a
complete description for the chemicals used,
their preparations, in addition
to Instruments and equipments, cell design
of ion selective
electrode and molecularly imprinted polymers and casting the membrane.
Chapter three consists of two
parts.
1- Ion selective
electrodes ISEs :
In this method estimation two
drugs : The
first ibuprofen ion selective electrodes have been prepared based on
dodeca phosphomolybdic acid (PMA) using many plasticizers which were:
di-butylphthalate (DBPH),tri-butylphosphate(TBP) , dioctylphthalate (DOPH) and nitro benzene (NB) in PVC matrix membranes. The
matrix membrane was formed by mixing an appropriate
plasticizer and drug complexes with
PVC. The following electrode parameters
including; concentration range, slope, detection limit, response time,
life time, correlation coefficient and the working pH range, also
interferences were studied via selectivity against monovalent, divalent and
trivalent such as ( Li+, Na+,Ca2+ ,Mg2+,Al3+and Fe3+) for all the
electrodes are studied by using separation solution method (SSM) and
match potential method (MPM) methods to determine the selectivity potential
coefficient (Kpot
A,B). The results showed that
membranes of the electrodes;
IBP-PMA+DBPH, IBP-PMA+TBP, IBP-PMA+DOPH and IBP-PMA+NB gave
a linear range from 1x10-5
to
1x10-1
M
respectively, with slopes of
(18.65, 15.4, 17.64 and 17.7) mV/decade. The limit of detection of
(8.5x10-6, 7.5x10-5, 4x10-4 and 3.5x10-5) M, response
time of 10-3M (23, 28, 22 and 34 second) and the lifetime
were about (40, 9, 35, and 19 days)
respectively. Correlation coefficient (0.9848, 0.9948, 0.9985 and
0.9977). The working pH ranges were ranged from (2.5 - 9.0). The
second drug is mefenamic acid in which different ion selective electrodes
have been prepared based on dodeca phosphomolybdic acid (PMA) and
dodeca phosphotungeston acid using two plasticizers which were:
di-butylphthalate (DBPH) and nitro benzene (NB) in PVC matrix membranes.
The matrix membrane was formed by mixing an appropriate plasticizer and
drug complexes with PVC. All characterization measured in ibuprofen
return with mefenamic acid the results showed that
membranes of the electrodes;
MFA-PMA+DBPH, MFA-PMA+NB, MFA PTA+DBPH and MFA-PTA+NB gave a linear range from 1x10-5 to
1x10-1
M
respectively, with slopes of (18.84, 17.11, 18.4 and 17.18) mV/decade.
The limit of detection of (9.3x10-5, 9.5x10-7, 7x10-5 and 8x10-6) M, response
time of 10-3M (18,32, 39 and
28 second) and the lifetime were
about (35, 12, 23, and 9 days) respectively. Correlation coefficient
(0.9990, 0.9987, 0.9991 and 0.9945). The working pH ranges were
ranged from (3.0 - 8.0). The practical utility of the above
electrodes have been used as
indicator electrodes in the potentiometric determinations
of Ibuprofen and Mefenamic acid , using direct and incremental
methods with successful and good results. Also, the IBP PMA+DBPH, IBP PMA+TBP, IBP-PMA+DOPH and IBP-PMA+NB electrodes
were used to determine Ibuprofen. And electrodes
MFAPMA+ DBPH, MFA-PMA+NB,
MFA-PTA+DBPH and MFA-PTA+NB were used to
determined mefenamic acid in the pharmaceutical samples.
2-Molecularly
Imprinted Polymers :
In
this method ibuprofen
molecularly imprinted polymer
have been prepared based on acrylamide and methacrylic
acid as monomers, ethylene glycoldimethacrylate and trimethylolpropanetriacrylate
as cross-linker and benzoyl peroxide as initiator. using
many plasticizers which were: di-butylphthalate (DBPH),oleic
acid (O.A) , paraffin (PRF) and orthonitrophenyloctyl ether (o-NPOE)
in PVC matrix membranes. The matrix membrane was formed by mixing
an appropriate plasticizer and polymers with PVC. The following
electrode parameters including; concentration range, slope, detection
limit, response time, life time, correlation coefficient and the working
pH range, also interferences were studied Via selectivity against monovalent,
divalent and trivalent such as ( Li+, Na+,Ca2+ ,Mg2+,Al3+and Fe3+) for all the
electrodes are studied by using separation solution
method (SSM) and match potential
method (MPM) methods to determine the
selectivity potential coefficient (Kpot A,B). The results showed
that membranes of the electrodes; IBP-ACY+EGDMA+DBPH, IBP-ACY+EGDMA+O.A,
IBP-MAA+TMPTA+PRF and IBPMAA+ TMPTA+ONPOE gave
a linear range from 1x10-5
to
1x10-1
M respectively,
with slopes of (-52.64, -45.32, -54.25 and -53.61) mV/decade. The
limit of detection of (1.09x10-6, 2.5x10-6, 9x10-6 and 5.65x10-6) M, response
time of 10-3M (35, 37, 43
and 51 second) and the lifetime were
about (26, 11, 12, and 19 days) respectively. Correlation coefficient
(0.9982, 0.9925, 0.9968 and 0.9888). The working pH ranges were ranged from (3.5 - 8.0).
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